A REVIEW ON FLOATING DRUG DELIVERY SYSTEM

Abstract

This article on the floating drug delivery system (FDDS) was written with the primary goal of organizing recent literature with the fundamental process of flotation in achieving gastric retention. The two approaches taken in the development of FDDS by creating both effervescent and non-effervescent floating tablets with a buoyancy mechanism as its foundation. With a limited window for absorption in the upper gastrointestinal tract, instability in the lower intestine environment, and low solubility at higher pH levels, FDDS is a way for delivering drugs. Physiological and formulation variability affecting gastric retention, and the utilization of recently produced and invented polymers are some examples of the novel methodologies in FDDS. This review also focuses on different in vivo and in vitro methods in relation to the functionality and use of floating systems. Floating dosage forms can be administered in conventional forms like tablets or capsules by including the gas-generating agent and the proper ingredients. This paper also discusses several methods for creating floating dosage forms, as well as recent and innovative developments.