IMPACT OF DIFFERENT EXCIPIENTS ON DISSOLUTION IMPROVEMENT OF LORATADINE BY SOLID DISPERSION

Abstract

Loratadine is one of the most commonly used anti-histamine. It is practically insoluble in water. The onset of the action of the Loratadine is delayed due to its poor aqueous solubility. Nowadays, solid dispersion is an emerging technology in the pharmaceutical industry to increase the solubility of poorly soluble drug by using different polymer/ excipients. In this study, Peg 6000, Poloxomer 188 & 407, HPC, HPMC, Crospovidone, Croscarmellose and Kollicoat IR were used to formulate solid dispersion of Loratadine. In case of HPMC formulations, significant % release of drug was observed within 10 minutes. With the increase of HPMC from 71% to 83%, release was increased from 61.86% to 71.88% after 60 minutes. HPMC based solid dispersion formulation can be a way to improve dissolution of loratadine in commercial production.